San Francisco Brewing Company is in the southwest corner of Ghirardelli Square and not accessible from the street.
Many people approach Ghirardelli Sq this way, from the shore.
If you look at Google Maps, everything is rotated 180 degrees.
For context, here is a zoomed out map. SF Brew Co is on the left, Pier 39 is toward the middle, and the Alcatraz ferry is on the right.